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Von Gierke, Pompe, Cori, McArdle — four diseases that become unforgettable once you see the warehouse logic behind them. Liver glycogen is the body's public bank; muscle glycogen is a private vault. Learn which enzyme is missing, and the symptoms, labs and exam traps derive themselves: fasting hypoglycaemia with lactic acidosis and gout, the floppy baby with the enormous heart, the milder Cori picture with intact gluconeogenesis, and McArdle's second wind with a flat lactate rise.
⏱ Chapters:
0:00 Two stems, one family
0:32 Two warehouses
1:15 The crossroads
1:48 Von Gierke (type I)
2:51 Pompe (type II)
3:52 Cori (type III)
4:41 McArdle (type V)
5:45 The family on one pass
Educational content only: this video teaches exam concepts (USMLE-style) and is not medical advice. Stock footage: Pexels (Pexels Licence). Diagrams drawn for this video. Narration: AI-generated voice (Helio) with human-written script — contains AI-generated audio.
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